Questions?

Whenever I see a research study there are questions that pop up. About how they gathered the data and how they analyzed it.

Parents groups react to study showing puberty blockers could cause permanent problems in boys: 'Unforgivable'
'The science, or lack thereof, has shown that we were right all along,' one parent group said
Fox News
By Kristine Parks
April 16, 2024

Parents groups sounded off on a new medical study which found fertility blockers could cause long-term fertility and health problems in boys.

The study from the Mayo Clinic, which has not yet been peer-reviewed, analyzed more than 130,000 sperm cells from male children with gender dysphoria. The researchers examined the testicular cells of boys who had been on puberty blockers anywhere from three months to 52 months, and compared them to cells of a control group who had not been on the blockers.

Among those on puberty blockers, the researchers identified mild to severe "sex gland atrophy," determining that the medications accelerated the aging and function of testicular cells.

The findings suggest that puberty blockers’ impacts may be permanent — disputing claims that such effects can be reversed.

First: When and how long were they tested after going off of puberty blockers. 6 months? A year? 5 years? Was it a longitudinal over many years? These are all important questions when reviewing the paper.

The researchers also detected cases of microlithiasis, which is marked by the presence of small clusters of calcium in the testicles. Testicular microlithiasis has been linked to an increased risk of testicular cancer.

Parents groups who have advocated against the use of transgender treatments on children told Fox News Digital they were thankful the study was attracting headlines.

What’s microlithiasis? I had to Google it.

Testicular microlithiasis (TM) is a rare condition where calcium clusters form in the testicles. It's usually asymptomatic and is often found during an ultrasound of the scrotum. TM is characterized by multiple small, echogenic foci scattered throughout the testicles, and can be unilateral or bilateral.

TM is believed to be found in 0.1–0.6% of males globally, with frequency varying based on geographic location and is more often found in individuals with subfertility. Studies have shown that a greater burden of TM can be associated with poorer sperm function.

Next question, how much of a deviation from normal is it?

This isn’t the only study that the conservative are pushing,

The group also pointed to a more comprehensive report out of the United Kingdom which found only "weak evidence" that blocking puberty helped in the treatment of minors suffering from gender dysphoria.

"For most young people, a medical pathway will not be the best way to manage their gender-related distress," one of the study's key findings read.

Remember question everything!

Perexity.AI: “What should look for when reviewing a research study?”

Answer:
Based on the search results, here are the key things to look for when reviewing a research study:

    Study Source

•         Identify where and when the study was published
•         Consider the credibility and reputation of the publication or organization that published the study

    Study Design and Methodology

•         Examine the research question, study design (e.g. case study, experiment), and analytical approach
•         Assess the appropriateness and rigor of the research methods used
•         Evaluate whether the methods are well-described and could be replicated
•         Consider the limitations and potential biases in the study design

    Study Findings and Analysis

•         Examine whether the data supports the research question and if the statistical analysis is appropriate
•         Look for any inconsistencies or gaps in the data
•         Assess the significance and implications of the results
•         Evaluate whether the authors provide a balanced and objective interpretation of the findings

    Study Relevance and Contribution

•         Consider whether the research problem is significant and the study makes a meaningful contribution
•         Assess the generalizability of the findings and their applicability to other populations or situations
•         Evaluate the ethical considerations of the study

    Writing Quality and Clarity23

•         Assess the overall structure, organization, and clarity of the writing
•         Consider whether the source reflects the conventions of the discipline
•         Identify any gaps, biases, or areas that need further clarification

By carefully examining these key aspects, you can provide a thorough, balanced, and constructive critique of the research study.