You All Have Seen Those Hateful Comments…

About XY and XX chromosomes or about our anatomy between our legs; well that is 1950s thinking, we have come a long ways since then to understand gender.

Scientists uncover 20 genes linked to being transgender – supporting claims the condition has a physical basis

• US researchers tested 14 female-to-male and 16 male-to-female patients
• The latest findings point towards transgender identity having a physical basis
• Dr Ricki Lewis, a geneticist, said: 'It lends legitimacy, if that needs to be added, that transgender is not a choice but a way of being'

The Daily Mail

By Colin Fernandez Science Correspondent
18 March 2018

Scientists have uncovered 20 genes linked to being transgender – supporting claims that the condition has a physical basis.

Researchers believe the gene variations may contribute to people identifying with the opposite sex.

Critics of transgender identity say the condition is ‘all in the mind’, and transgender people have a psychological problem rather than a medical one. But by highlighting genetic mutations that affect brain development, the latest findings point towards transgender identity having a physical basis.
[…]
‘The most promising of these include variants of genes involved in neurologic development and sex hormones.’

Dr Ricki Lewis, a geneticist, said: ‘These are highly reputable folks going about this exactly the right way, searching the genomes of transgender people to highlight which genes they have variants in. It lends legitimacy, if that needs to be added, that transgender is not a choice but a way of being.'

Then there is this article…

What Role Do Sex Chromosomes Play In Transgender People's Identities?
Forbes
Quora , Contributor
Match 19, 2018

What role do sex chromosomes play in the identities of transgender people? originally appeared on Quora: the place to gain and share knowledge, empowering people to learn from others and better understand the world.
Answer by Sai Janani Ganesan, Postdoctoral Scholar at UCSF, on Quora:
Biological gender and gender identity are two very distinct concepts. Biological gender or sex refers to the anatomy and physiology of a human body, whereas gender identity is influenced by a multitude of factors, most of which we don’t fully understand.

Biological sex is purely determined by the choice of sexual differentiation pathway, which is guided by genes on the sex chromosomes (though not exclusively, for example: WNT4 on chromosome 1). Testis-determining factor (TDF) or sex determining gene Y (SRY) located on the Y chromosome is one such gene. SRY is largely responsible for testis formation. It is not the only gene, and a variety of pathways and proteins are involved in this process of sex differentiation, some even located in the autosomal regions, but SRY is… special.

The sex determining gene Y (SRY) was identified in the 1980s by Peter Goodfellow’s group [2]. Goodfellow’s group and others performed a series of experiments to demonstrate the role of the gene. In one such study, they looked at the genetic information of individuals who were anatomically female and had both XY chromosomes, and individuals who were anatomically male with XX chromosomes [3][4]. They found the SRY gene in an X chromosome in fifty cases of anatomically male with XX chromosomes. In one of the anatomically female case with XY chromosomes, they found a single nucleotide mutation in the SRY gene, that translated to a single amino acid change (from methionine to isoleucine), thus disrupting the testes development process. A single amino acid change from methionine to isoleucine in the SRY gene can cause an embryo with XY sex chromosomes to develop as a female. It is not difficult to imagine that such de novo mutations can also play a role in gender identity. In another study in 1991, they were able to transform female mice embryo to male (anatomically and behaviorally) by simply inserting one single SRY gene [5].

The thing to remember is that there may be many reasons why we are trans and just because you don’t have one medical indicator doesn’t mean you’re not trans. There is only one sure thing that indicates if you are trans or not and it is you. You are the final judge if you are trans.